Date of latest revision: 4 Dec 2019
You will find here examples of people who suffered severe toxic reactions to 5-FU chemotherapy treatment. Pre-screening for DPD deficiency could have averted the problems these individuals endured. The type of pre-screening does matter: In the case of Linda here, her family had her tested for the DPD deficiency, post-mortem, but found no genetic deficiency. The type of "functional", not genetic, test performed by Dr. Ciccolini (see Hope) may have been useful in helping Linda avoid the toxic reaction and suffering stemming from her treatment.
You may also view the video recorded in 2016 for the purposes of educating people of the risks associated with 5-FU and capecitabine chemotherapy. This is hosted on a site promoting the use of Vistogard, the antidote for "over dosing". The antidote is helpful but the first course of action, in my opinion, is to screen patients before the start of treatment to minimize the number of severe toxicities suffered.
The 5FU Test Alliance advocate group in the UK launched its website in November 2019. There you will find compelling videos of people who suffered as a result of misguided 5FU treatment practices -- misguided in that no testing was offered or performed. See: https://www.5futestalliance.org/videos/
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